1346_MG_9522_MG_95311315

Deliquescing (2015)
Lion’s Mane mushroom grow block on stainless steel trolley, Polaroid on aluminium shelf.

Nerve growth factor (NGF) is closely related to Alzheimer’s disease, and studies have suggested that the disease may be prevented or its symptoms may be improved when NGF is given into the brain directly. However, since NGF is a protein it usually cannot pass through the blood-brain barrier. Recently, researchers have targeted on the substances that could pass through the blood-brain barrier and induce NGF synthesis in the brain. Some compounds with lower molecular weight have been found to have such bioactivity. Among these bioactive compounds, hericenones and erinacines, which were isolated from an edible mushroom called as Lion’s Mane (Hericium erinaceus), showed remarkable activity of stimulating the synthesis of NGF. They could be developed as a dietary supplement or medicine to be used for treating Alzheimer’s disease.

Kawagishi, H, et al “The Inducer of the Synthesis of Nerve Growth Factor from Lion’s Mane (Hericium erinaceum)” Explore! Vol. 11, No. 4, 2002.